产品货号：
GS4753
中文名称：
重组人Galectin-3
英文名称：
Recombinant Human Galectin-3
产品规格：
10μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 26.0kDa,a single non-glycosylated polypeptide chain containing 249 amino acids.
储存条件：冷冻（-20℃）
概述
Human Galectin-3 also named AGE-R3,CBP35,GAL3,L29,LGALS3,Mac-2,is belonging to the galectins family and it is encoded by a single gene,LGALS3,located on chromosome 14,locus q21–q22.It is expressed in the nucleus,cytoplasm,mitochondrion,cell surface,and extracellular space.Galectin-3 is approximately 30 kDa and,like all galectins,contains a carbohydrate-recognition-binding domain(CRD)of about 130 amino acids that enable the specific binding of β-galactosides.Given Galectin-3’s broad biological functionality,it has been demonstrated to be involved in cancer,inflammation and fibrosis,heart disease,and stroke.Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure,including myofibroblast proliferation,fibrogenesis,tissue repair,inflammation,and Ventricular remodeling.Human Galectin-3 shares 79%amino acid sequence identity with rat and mouse Galectin-3,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人Galectin-3，Galectin-3, Human，Recombinant Human Galectin-3
储存条件：冷冻（-20℃）
概述
Human Galectin-3 also named AGE-R3,CBP35,GAL3,L29,LGALS3,Mac-2,is belonging to the galectins family and it is encoded by a single gene,LGALS3,located on chromosome 14,locus q21–q22.It is expressed in the nucleus,cytoplasm,mitochondrion,cell surface,and extracellular space.Galectin-3 is approximately 30 kDa and,like all galectins,contains a carbohydrate-recognition-binding domain(CRD)of about 130 amino acids that enable the specific binding of β-galactosides.Given Galectin-3’s broad biological functionality,it has been demonstrated to be involved in cancer,inflammation and fibrosis,heart disease,and stroke.Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure,including myofibroblast proliferation,fibrogenesis,tissue repair,inflammation,and Ventricular remodeling.Human Galectin-3 shares 79%amino acid sequence identity with rat and mouse Galectin-3,respectively.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞98%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by its ability to agglutinate human red blood cells is less than 10μg/ml. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in 1×PBS,pH 7.4,3mMDTT. |
| 内毒素 | Less than 0.1 EU/μg of rHuGalectin-3 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYPGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSATGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SK |
相关搜索：重组人Galectin-3，Galectin-3, Human，Recombinant Human Galectin-3